diff --git a/src/Sortable.js b/src/Sortable.js
index 048a38b1ce67a4f5aa4e55d8bd556ee1d020ba3f..a509a83c507bef09049a18f14e325ef6b2332254 100644
--- a/src/Sortable.js
+++ b/src/Sortable.js
@@ -484,6 +484,11 @@ Sortable.prototype = /** @lends Sortable.prototype */ {
 			return;
 		}
 
+		// Safari ignores further event handling after mousedown
+		if (!this.nativeDraggable && Safari && target && target.tagName.toUpperCase() === 'SELECT') {
+			return;
+		}
+
 		target = closest(target, options.draggable, el, false);